DNP + Supplement “Stacks” for Optimal Effect

Taken alone, DNP is already capable of producing dramatic fat loss.  Losses of muscle and lean mass are minimal, too, especially if properly designed workouts are performed.


These effects, while already substantial, can be further enhanced in at least three different ways through strategic combinations of DNP and other supplements.




The baseline protein-sparing and lipolytic (fat-burning) effects of DNP are already substantial, but can be augmented further by supplements that mobilize body fat for lipolysis.  Two kinds of supplements are ideal, with the choice depending on the user’s current level of body fat.


DNP + Clenbuterol (for males over 10% body fat, or females over 20% body fat):

Clenbuterol, a beta-2 adrenergic agonist, mobilizes stored body fat for lipolysis.  Taken with DNP, it can shift the body’s metabolic balance further toward lipolysis (fat burning), actively aiding the ability of DNP to burn stored fat.  In addition, studies show that clenbuterol itself has anti-catabolic and perhaps even anabolic effects, so the combination of DNP and clenbuterol is even more likely to allow the user to preserve lean muscle.

Clenbuterol does not mobilize “stubborn” fat stores (the last reserves of subcutaneous fat), for which lipolysis is instead modulated by alpha-2 adrenergic receptors.  Therefore, for users who are already quite lean (at most 10% body fat for males, 20% for females), clenbuterol will have a lesser effect on the fat loss caused by DNP.  For lean DNP users, yohimbine (see below) is a better choice.

The effect of clenbuterol on DNP and fat loss will be most pronounced if the clenbuterol is taken 30-60 minutes before light to moderate cardio exercise, under conditions of fasting or low carbohydrates.


DNP + Yohimbine (for males under 10% body fat, or females under 20% body fat):

Yohimbine, an alpha-2 adrenergic antagonist, allows for greater burning of the body’s “stubborn” fat stores.  If taken with DNP by a suitably lean athlete, it will mobilize the body’s last reserves of stored fat—usually in the abdomen and/or hips—and thus amplify the lipolytic effect of DNP.

Like clenbuterol, yohimbine is best taken 30-60 minutes before light to moderate exercise.  The optimum dose is approximately 0.2 mg multiplied by body weight in kg, or 0.1 mg multiplied by body weight in pounds).

The pro-lipolytic effect of yohimbine is completely abolished by insulin (produced by the body in response to carbohydrate intake).  Therefore, lean DNP users aiming for maximum fat loss MUST take yohimbine under conditions of fasting or extremely low carbohydrates.




The metabolic acceleration caused by DNP can cause intense hunger, especially in the form of carbohydrate cravings.  Since DNP itself has no anorectic (appetite-suppressing) effects, supplemental appetite suppressants can be helpful.


DNP + Ephedrine + Caffeine (DNP + “EC stack”):

Many users find the combination of ephedrine and caffeine useful in curbing appetite and carbohydrate cravings.  The ephedrine/caffeine stack (in the ratio of 10mg caffeine per 1mg ephedrine) may thus be a useful adjunct to DNP, especially for athletes who are very lean and/or consuming a low-calorie/low-carbohydrate diet.  Bodybuilders in the contest preparation stage, in particular, often find the EC stack indispensable as an appetite suppressant.

The ephedrine/caffeine stack has thermogenic (fat burning) properties, but they are negligible compared to those of DNP.


Users taking prescription medicines with an anorectic effect (e.g., Adderall, dextroamphetaminc, bupropion) may find those medicines useful in keeping hunger and carbohydrate cravings at bay.




The use of DNP has been compared by some to “24-hour-a-day cardio”, and not without reason: DNP increases the body’s base metabolic rate—around the clock—to the levels normally achieved by light to moderate aerobic exercise.  Just as spending all day walking would make one tired, DNP too can cause a sense of fatigue, specifically drowsiness and/or physical exhaustion.  For users who need to stay busy while taking DNP, supplements to increase alertness can help.


DNP + Adrafinil:

Adrafinil is an herbal supplement that is converted by the body (via the liver) into modafinil, a light stimulant that promotes wakefulness and attention.  This metabolite is very effective against drowsiness, physical exhaustion, and sleep deprivation; it is commonly prescribed to shift workers, military pilots, emergency responders, and others who need to stay alert around the clock.  150 to 300 mg of adrafinil, taken once or twice per day, can help alleviate any fatigue caused by DNP.


Dosing for DNP is discussed here.


Learn about the chemistry and action of DNP here.


Click here to read more about DNP and calorie consumption.


To read more about the effects of DNP on different bodybuilding diets, click here.


Read about workouts to preserve lean mass here.